M O I L A B

from molecular evolution to global change ecology

Our questions and mission Will species evolve to climate change? Can evolution from pre-existing genetic diversity in species lead to rapid evolution to the environment? What is the genomic architecture of adaptation? What are the eco-physiological and life history traits involved in plant climate adaptation? Can we use novel molecular biology to engineer adaptation? Can we deploy global monitoring technologies to track and diagnose species and ecosystem declines and reliably guide sustainability policies?

Expertise and group research To address the above questions, our lab integrates multiple disciplines, from plant experimental ecology, to evolutionary genetics, to molecular biology, and computer science. Some of our work has dealt with understanding the rate at which new DNA mutations occur per generation in plant populations, what is the ecological relevance of genetic variation along the genome. We have pioneered methods to create geographic maps cataloging genetic variation of a species to anticipate the differential threats of climate change to its different populations. An important current project of the lab is a distributed global evolution experiment, GrENE-net.org, which aims to test the evolvability of the plant Arabidopsis thaliana in many climates around the world. Using the same plant model, we are trying to modify adaptive ecological traits in the lab using CRISPR-based genome editing. We have also created methods to track the loss of evolutionary potential of species from habitat losses. We hope our efforts will help us to fundamentally understand evolution, ecology, and genetics, of a species in relation to climate.

Diversity, equity, inclusion, belonging, and justice. We strive to be and welcome a diverse and inclusive lab and scientific community, and denounce racism, xenophobia, and any kind of violence.

Open science We make our research open to the public, posting papers on bioRxiv.org and making code and data available GitHub.com, Datadryad.org, or Figshare.com. PDFs of all of our publications can also be found under subpage papers.

Affiliations and home. As of 2024, our lab is homed at the University of California Berkeley (www.berkeley.edu), department of Integrative Biology (ib.berkeley.edu, Center for Theoretical Evolutionary Genetics), the Howard Hughes Medical Institute (www.hhmi.org), and is affiliated member to the Institute of Innovative Genomics (innovativegenomics.org).

Our lab was founded in 2019 at the Department of Plant Biology of the Carnegie Institution for Science and Stanford University.

Latest news & blog posts

2024 10 21 Moi will be attending delegate in the United Nations' Convention on Biological diversity
A key goal is to evaluate how targets approved in Dec 2022 in the Kunming Montreal Global Biodiversity Framework, and will also has a focus on how to finance biodiversity projection in the future.

Moi is putting resources together especifically about genetic diversity targets under evaluation
https://moilab.science/cop16

Including a new manuscript from Kristy Mualim et al. to be posted shortly in bioRxiv.com with new predictions of genetic diversity loss in the Anthropocene

https://drive.google.com/file/d/1G8ZIaTKlPYhHKKMC-jCdNcmfLQTcGifk/view?usp=sharing

Mualim_etal_2024_combined.pdf

2024 10 09 Very proud University of California Berkeley is the #1 public university by Times Higher Education
Very nice to see our University showcases excellence can go hand in hand with making education broadly available, accessive, and inclusive, rivaling or surpassing Ivy league universities!
https://www.timeshighereducation.com/world-university-rankings/latest/world-ranking#!/length/25/sort_by/rank/sort_order/asc/cols/scores

#MOILAB summer talks and posters

SMBE 2024 Mexico

Kristy Mualim - poster Wednesday, 10th July, 1.30pm "Unveiling the functional dynamics of noncoding DNA: A deep learning approach with Arabidopsis thaliana"

ICAR 2024 San Diego

Moi - talk Wednesday, 17 5:54 pm " Rapid evolution to climates along

the Arabidopsis genome"

Jinseul Kyung - poster Tuesday, 16th July, 8pm "Disentangling the genetic trade-offs between flowering time and water use efficiency"

Evolution 2024 Montreal

Laura Leventhal - talk Monday July 29, 10am, "Four range limit hypotheses tested in a climate manipulated common garden"

Kristy Mualim - talk Saturday, 27th July, 9.45am. "Genetic diversity loss continues long after habitat destruction ends"

Tatiana Bellagio - talk July 28, 2024 at 3 30 pm "Polygenicity effects on rapid adaptation to new environments"

Moi - talk July 29, 2024, 4:15 PM " Rapid evolution to climates along

the Arabidopsis genome"

Ecological Society of America 2024 Montreal

Laura Leventhal - talk August 8, time TBD, "The impact of population genetic makeup along an environmental gradient: insights from an Arabidopsis common garden"

IPREP DOE meeting Normal, Illinois

Xing Wu - talk Aug 1st. 739 "Genomes Reveal Natural Variation and Adaptation History in Pennycress"

GRC Salt and Drought stress

Moi - talk TBD " Rapid evolution to climates along the Arabidopsis genome"

Moi received the Spanish' Princess of Girona price for his work on evolutionary adaptation of species to climate change

Press: https://www.fpdgi.org/es/actualidad/noticias/moises-exposito-alonso-premio-princesa-de-girona-investigacion-2024-2/

2024 09 05 Lauren's paper came out in PNAS!

https://www.pnas.org/doi/10.1073/pnas.2318296121

Press release: https://news.berkeley.edu/2024/10/11/using-ai-and-inaturalist-scientists-build-one-of-the-highest-resolution-maps-yet-of-california-plants/

Laura receives the 2024 ASN Student Research Award for her work investigating the genetic and environmental determinants of rapid adaptation through field experiments

Press release: https://www.amnat.org/announcements/Student-Research-Award-2024.html

Moi presenting his Tansley Medal talk at New Phytologist Now
Register link -> https://us02web.zoom.us/webinar/register/5816970187871/WN_ZtWKtIxnRaavGldkg0eQAw#/registration

Editorial: The New Phytologist Tansley Medal 2022
(doi: 10.1111/nph.18741)
Profile: Moi Exposito-Alonso
(doi: 10.1111/nph.18735)
Tansley insight: Exposito-Alonso (2023) Understanding local plant extinctions before it’s too late: bridging evolutionary genomics with global ecology
(doi: 10.1111/nph.18718)

#MOILAB presenting at GEO BON global conference

Oct 11 9:30 AM Kristy Mualim "Dynamics of genetic diversity loss after habitat loss" (International I)

Oct 11 9:30 AM Oliver Selmoni "From satellites to genes: predicting coral evolution in warming oceans" (International I)

Oct 11 11:30 AM Moi Exposito-Alonso "Predicting genetic diversity loss in the Anthropocene" (International II)

Oct 11 11:30 AM Lauren Gillespie "Mapping plant biodiversity from the skies using open science, remote sensing, and deep learning" (International II)

2023 09 14 The #MOILAB is moving to BERKELEY in 2024!

We are super excited to announce the news of our lab's next, long-term phase at the University of California Berkeley. Our lab will also begin at the same time its phase as part of the Howard Hughes Medical Institute (HHMI).

This new home will continue catalyzing our strong evolutionary genetics research area within the Center for Theoretical Evolutionary Genetics, and allow us to expand into new directions of global biodiversity, with links to the UC & Jepson Herbaria, and supercharge the lab's efforts in gene editing as member of the Innovative Genomics Institute.

We are recruiting at all levels (PhD students, tech, Postdoc, Staff Scientists) to join this new lab adventure!

https://twitter.com/MExpositoAlonso/status/1702411534004363633
https://bsky.app/profile/mexpositoalonso.bsky.social/post/3k7ex4vshi22r
https://www.linkedin.com/feed/update/urn:li:activity:7108179290957000705/

#MOILAB presenters at Ecology Society of America 2023

Aug 9 10:00 AM Lauren Gillespie "Mapping plant communities from above using deep learning, citizen science, and remote sensing" (Room TBD)

Aug 7 at 1:50 PM Meixi Lin "Genetic extinction vortex: feedbacks between species range and adaptability loss in the Anthropocene" (Room 258)

#MOILAB presenters at Society of Molecular Biology & Evolution 2023, GRC Ecological and Evolutionary Genomics, and American Society of Plant Biology 2023

July 26 at 10:30 am Moi Exposito-Alonso. "The genomics of species range contraction in the Anthropocene" (New Frontiers in Conservation Genomics) (Location: AD1)

July 31 at 7:40 pm Moi Exposito-Alonso "The Genomics of Adaptation and Extinction in the Anthropocene"

Aug 2 at 1:45 pm Moi Exposito-Alonso. "Rapid evolution across climates in globally-distributed experiments of an annual herb" (Location: Meeting Room 105-106)

#MOILAB presenters at Botany 2023

July 24 at 2:15 pm Laura Leventhal. "Four range limit hypotheses tested in a climate manipulated common garden using natural accessions of Arabidopsis thaliana" (Ecology 2: Plant Responses to the Environment)

#MOILAB presenters at Evolution 2023

June 22 - 11:15 AM @ Pecos 230 - Lauren Gillespie "Mapping plant biodiversity from the skies using open science, remote sensing, and deep learning" (Biogeography II session)

June 22 - 3 PM @ Mesilla 235 - Tatiana Bellagio "Benchmarking GEA models to identify rapid evolution across climates in globally-distributed experiments of an annual herb" (Experimental Evolution I)

June 22 3:15 PM @ Pecos 230 - Kristy Mualim "Genetic diversity loss continues long after habitat destruction ends" (Conservation Biology I)

June 23 10:15 AM @ Pecos 230 - Laura Leventhal "Four range limit hypotheses tested in climate-manipulated common garden" (Adaptation III)

June 23 - 4:30 PM @ Brazos 115 - Lucas Czech "Population genetic statistics for the next generation of pool sequencing" (Population Genetics Theory - Methods II)

2023 05 20 Lucas' grenedalf software is in arXiv!

Lucas created a tool for manipulating and conducting statistics for pool-sequencing data to study rapid evolutionary dynamics!

https://arxiv.org/abs/2306.11622
https://twitter.com/MExpositoAlonso/status/1671321863627198473

2023 05 25 BIG UPDATE on Lauren's deepbiosphere in bioRxiv! Lauren used deep learning to connect high-resolution airborne images with plant species reported in iNaturalist in a new generation of niche models!

https://doi.org/10.1101/2022.08.16.504150
https://twitter.com/MExpositoAlonso/status/1661774330961993728

2023 2 16 Moi is recognized with the Early Career Faculty Award from the American Society of Plant Biology for exelence in plant genetics!

https://blog.aspb.org/congratulations-to-2023-aspb-award-recipients/

2023 5 9 The Howard Hughes Medical Institute (HHMI) selected Moi as one of the 31 new Freeman Hrabowski Scholars, outstanding early career faculty in science who have potential to become leaders in their research fields and to create diverse and inclusive lab environments in which everyone can thrive.

https://www.hhmi.org/news/hhmi-names-31-inaugural-freeman-hrabowski-scholars

#FHScholars @HHMINEWS

2023 5 Xing got awarded the postdoc fellowship of the Stanford center for Computational, Evolutionary and Human Genomics. Congrats Xing!
https://cehg.stanford.edu

2023 2 16 Moi is recognized with the Tansley Medal for exelence in plant science!

Editorial: The New Phytologist Tansley Medal 2022
(doi: 10.1111/nph.18741)
Profile: Moi Exposito-Alonso
(doi: 10.1111/nph.18735)
Tansley insight: Exposito-Alonso (2023) Understanding local plant extinctions before it’s too late: bridging evolutionary genomics with global ecology
(doi: 10.1111/nph.18718)

2023 2 10 Meixi awarded the prestigious Smith Fellowship for conservation!

https://conbio.org/mini-sites/smith-fellows

https://twitter.com/SmithFellows/status/1624120332175933449

https://conbio.org/publications/scb-news-blog/scb-welcomes-the-class-of-2023-smith-fellows

2022 12 09 Moi appears in mainstream Spanish newspaper El Pais talking about global biodiversity targets

https://elpais.com/ciencia/2022-12-09/moises-exposito-alonso-sobre-la-extincion-silenciosa-el-antropoceno-ya-ha-provocado-una-perdida-de-biodiversidad-irremplazable.html

2022 12 07 Moi will be attending delegate in the United Nations' Convention on Biological diversity!
Follow https://twitter.com/MExpositoAlonso in Twitter for updates on genetic diversity goal discussions

https://www.unep.org/events/conference/un-biodiversity-conference-cop-15

https://www.cbd.int/side-events/

Moi is putting resources together about genetic diversity targets under www.moilab.science/cop15!

2022 10 25 New collaborative preprint with Bergmann lab led by Patricia Lang on Arabidopsis herbaria to track adaptation to climate change!

https://www.biorxiv.org/content/10.1101/2022.10.23.513440v1
Twitter thread from Patricia Lang https://twitter.com/plantricia/status/1585296493849649154

2022 09 22 The MOILAB publishes a paper in Science magazine! We study how the loss of habitat for a species impacts its genetic diversity!

Read Moi's interview in The Scientist https://www.google.com/url?q=https%3A%2F%2Fwww.the-scientist.com%2Fnews-opinion%2Fare-we-in-the-midst-of-a-silent-mass-extinction-70534&sa=D
Press Release https://carnegiescience.edu/news/it-may-already-be-too-late-meet-un-genetic-diversity-target
La traducción en La Vanguardia https://www.lavanguardia.com/natural/20220923/8540552/antropoceno-provocado-destruccion-mas-10-diversidad-genetica-planeta.html

2022 09 05-18 Moi talking in the EPFL in Switzerland for its 20th anniversary of life sciences, SMBE symposium in Evolutionary Rescue in Kiel Germany, and WeigelFest in the Max Planck of Biology Tübingen in Germany.

2022 08 The MOI LAB got a multidisciplinary grant with Moi as co-PI! The grant is a new NSF Biology Integration Institute called WALII "Water and Life Interface Institute"

Check out the website! walii.science
NSF announcement: https://beta.nsf.gov/news/integrative-biological-science-and-training-are-focus-4-new-institutes

2022 08 16 Lauren's paper "deepbiosphere" is out in bioRxiv! Lauren used deep learning to connect high-resolution airborne images with plant species reported in iNaturalist in a new generation of niche models!

https://doi.org/10.1101/2022.08.16.504150

2022 08 077 Lauren talking at the Ecological Society of America! Explaining her new bioRxiv paper to create multi-species distribution models with satellite data!

Preprint http://dx.doi.org/10.1101/2022.08.16.504150

2022 06 27 Moi talking at the WorldBiodiversityForum.org! Explaining and giving global projections of genetic diversity loss.

Preprint https://www.biorxiv.org/content/10.1101/2021.10.13.464000v1

2022 06 07 Moi Lab at PEGQ22!

Laura presented her poster on a new outdoor field experiment (link here), Megan presented her poster on genetic constraints to adaptation (link here), Lucas presented his poster on grenepipe & grenedalf tools (link here) for the GrENE-net project. Moi presented his poster on genetic diversity loss (link here).

2022 02 04 Preprint led by Lucas and Ru in bioRxiv "Monitoring rapid evolution of plant populations at scale with Pool-Sequencing"!
This is the first of a saga of papers about the globally-distributed evolution experiment with A thaliana called GrENE-net

2022 1 12 Collaborative paper led by Grey Monroe and colleagues in Nature "Mutation bias reflects natural selection in Arabidopsis thaliana"!

2021 11 15 The lab led by graduate student Laura Leventhal with lot's of support from postdoc Megan Ruffley and other lab members just launched the largest Arabidopsis field experiment!

More pics here

2021 11 New collaborative paper with the Dinneny lab in bioRxiv! "Uncovering natural variation in root system architecture and growth dynamics using a robotics-assisted phenomics platform"
Preprint https://www.biorxiv.org/content/10.1101/2021.10.13.464000v1

2021 03 New collaborative paper with Joseph Matheson and Joana Masel in bioRxiv! "Haldane's cost of selection imposes a mild constraint on adaptation, with a high proportion of deaths in A. thaliana being selective"
Preprint https://www.biorxiv.org/content/10.1101/2021.10.13.464000v1

2021 10 16 New collaborative paper with the Vasseur & Violle labs in bioRxiv! "Into the range: a latitudinal gradient or a center-margins differentiation of ecological strategies in Arabidopsis thaliana?"
Preprint http://dx.doi.org/10.1101/2021.10.15.461205

2020 10 - 2021 10 Moi featured in "Fascination of Science" book and art exhibition featuring 60 Nobel prizes and 4 young researchers by the photographer and artist Herlinde Koelbl

click here

2021 10 15 New lab paper in bioRxiv! Quantifying how much genetic diversity is lost due to global change-driven ecosystem transformations will help track progress in the United Nation's sustainability goals. Congrats everyone!

Preprint https://www.biorxiv.org/content/10.1101/2021.10.13.464000v1
Twitter thread https://threadreaderapp.com/thread/1449158576975482880.html

2021 08 04 Graduate student Lauren Gillespie presenting her research at the Ecological Society of America meeting! Go Lauren!

2021 07 06 Collaborative paper with the Rhee and Gitler labs out in Cell -- including Moi and Postdoc Researcher Shannon Hateley!
https://carnegiescience.edu/news/how-seeds-know-its-good-time-germinate

2021 06 24 Graduate student Laura Leventhal was awarded the Lewontin Early Award from the Society for the Study of Evolution! Congrats Laura!

2021 06 23 Postdoc Researcher Megan Ruffley was awarded the Plant Genome Postdoctoral Research Fellowship in Biology from the National Science Foundation! Congrats Megan! [read Carnegie's PR]

2021 06 24 Moi presenting at ICAR 2020!
*Rapid evolution in globally-distributed field experiments of A. thaliana* Aka. the @GrENE_net project
Jun 24 - 3 pm (PST)

2021 06 21 Moi and Lucas presenting talks at Evolution 2021!
*Efficient analysis of allele frequency variation from whole-genome pool-seq data*
Jun 21 - 2:20 pm (PST) [VIDEO MP4]
*Rapid evolution in globally-distributed field experiments of A. thaliana* Aka. the @GrENE_net project
Jun 21 - 7 am (PST) [VIDEO MP4]

moiexpositoalonso-evolution21.mp4

Lucas evolution 2021 talk.mp4

2021 03 30 A new paper by Lucas Czech describing his "grenepipe" pipeline was published on arXiv.org! software on Github!

2021 02 10 A new paper by C Rellstab, B Dauphin and Moi just came out in Evolutionary Applications

2021 01 14 Graduate student Lauren Gillespie is giving a talk at NASA JPL on her satellite 2 species prediction model "deepbiosphere"

2021 01 11 Moi giving a talk in the Young Investigator Prize symposium at the American Naturalist 2021 Meeting #VirtualAsilomar2021

2020 12 17 Moi hablando en "El Pais con tu futuro"

https://elpais.com/educacion/2020-12-17/el-pais-con-tu-futuro-el-evento-para-inspirarte-a-la-hora-de-elegir-tu-carrera-profesional.html

https://elpais.com/elpais/2020/12/18/actualidad/1608301750_814442.html

2020 12 7-11 Lauren speaking in Women in Machine Learning section @ NeurIPS and AGU presenting her work on Deep Learning of biodiversity with remote sensing and user identifications of species!